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Splenic cords consist of the now-familiar loosemeshwork of reticular cells and reticular fibers that containtype III and type V collagen molecules. Normal matrix turnoverdepends on the ability of the chondrocytes to detect changesin matrix composition.
Grade 4 complications include myocardial infarction (1.3%–3.5%), septic shock(2.8%–4.5%), cerebrovascular accident (0.4%–0.7%), and pulmonary embolism (1.8%–3.2%).